Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.
Identifieur interne : 000068 ( 1957/Analysis ); précédent : 000067; suivant : 000069Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.
Auteurs : Kortney M. Gustin [États-Unis] ; Taronna R. Maines ; Jessica A. Belser ; Neal Van Hoeven ; Xuihua Lu ; Libo Dong ; Irina Isakova-Sivak ; Li-Mei Chen ; J Theo M. Voeten ; Jacco G M. Heldens ; Han Van Den Bosch ; Nancy J. Cox ; Terrence M. Tumpey ; Alexander I. Klimov ; Larisa Rudenko ; Ruben O. Donis ; Jacqueline M. KatzSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (analyse), Culture virale (), Excrétion virale, Furets, Mâle, Protection croisée (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (immunologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Vaccins inactivés (immunologie), Vaccins synthétiques (immunologie).
- MESH :
- analyse : Anticorps antiviraux.
- génétique : Sous-type H5N1 du virus de la grippe A, Vaccins atténués.
- immunologie : Protection croisée, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés, Vaccins synthétiques.
- Animaux, Culture virale, Excrétion virale, Furets, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (analysis), Cross Protection (immunology), Ferrets, Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (immunology), Male, Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Vaccines, Inactivated (immunology), Vaccines, Synthetic (immunology), Virus Cultivation (methods), Virus Shedding.
- MESH :
- chemical , analysis : Antibodies, Viral.
- genetics : Influenza A Virus, H5N1 Subtype, Vaccines, Attenuated.
- immunology : Cross Protection, Influenza A Virus, H5N1 Subtype, Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated, Vaccines, Synthetic.
- methods : Virus Cultivation.
- Animals, Ferrets, Male, Virus Shedding.
Abstract
Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cross-clade protection against this rapidly evolving virus. We report a comparative evaluation in ferrets of the immunogenicity and cross-protective efficacy of isogenic mammalian cell-grown, live attenuated influenza vaccine (LAIV) and adjuvanted, whole-virus, inactivated influenza vaccine (IIV), produced from a clade 1 H5N1 6:2 reassortant vaccine candidate (caVN1203-Len17rg) based on the cold-adapted A/Leningrad/134/17/57 (H2N2) master donor virus. Two doses of LAIV or IIV provided complete protection against lethal homologous H5N1 virus challenge and a reduction in virus shedding and disease severity after heterologous clade 2.2.1 H5N1 virus challenge and increased virus-specific serum and nasal wash antibody levels. Although both vaccines demonstrated cross-protective efficacy, LAIV induced higher levels of nasal wash IgA and reduction of heterologous virus shedding, compared with IIV. Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection.
DOI: 10.1093/infdis/jir596
PubMed: 21957153
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000159
- to stream PubMed, to step Curation: 000159
- to stream PubMed, to step Checkpoint: 000165
- to stream Ncbi, to step Merge: 000693
- to stream Ncbi, to step Curation: 000693
- to stream Ncbi, to step Checkpoint: 000693
- to stream Main, to step Merge: 000C86
- to stream Main, to step Curation: 000C81
- to stream Main, to step Exploration: 000C81
- to stream 1957, to step Extraction: 000068
Links to Exploration step
pubmed:21957153Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.</title><author><name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M" last="Gustin">Kortney M. Gustin</name><affiliation wicri:level="2"><nlm:affiliation>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R" last="Maines">Taronna R. Maines</name></author><author><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A" last="Belser">Jessica A. Belser</name></author><author><name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name></author><author><name sortKey="Lu, Xuihua" sort="Lu, Xuihua" uniqKey="Lu X" first="Xuihua" last="Lu">Xuihua Lu</name></author><author><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name></author><author><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name></author><author><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name></author><author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name></author><author><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O" last="Donis">Ruben O. Donis</name></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M" last="Katz">Jacqueline M. Katz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21957153</idno><idno type="pmid">21957153</idno><idno type="doi">10.1093/infdis/jir596</idno><idno type="wicri:Area/PubMed/Corpus">000159</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000159</idno><idno type="wicri:Area/PubMed/Curation">000159</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000159</idno><idno type="wicri:Area/PubMed/Checkpoint">000165</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000165</idno><idno type="wicri:Area/Ncbi/Merge">000693</idno><idno type="wicri:Area/Ncbi/Curation">000693</idno><idno type="wicri:Area/Ncbi/Checkpoint">000693</idno><idno type="wicri:Area/Main/Merge">000C86</idno><idno type="wicri:Area/Main/Curation">000C81</idno><idno type="wicri:Area/Main/Exploration">000C81</idno><idno type="wicri:Area/1957/Extraction">000068</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.</title><author><name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M" last="Gustin">Kortney M. Gustin</name><affiliation wicri:level="2"><nlm:affiliation>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R" last="Maines">Taronna R. Maines</name></author><author><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A" last="Belser">Jessica A. Belser</name></author><author><name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name></author><author><name sortKey="Lu, Xuihua" sort="Lu, Xuihua" uniqKey="Lu X" first="Xuihua" last="Lu">Xuihua Lu</name></author><author><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name></author><author><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name></author><author><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name></author><author><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name></author><author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name></author><author><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O" last="Donis">Ruben O. Donis</name></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M" last="Katz">Jacqueline M. Katz</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (analysis)</term><term>Cross Protection (immunology)</term><term>Ferrets</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Male</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Inactivated (immunology)</term><term>Vaccines, Synthetic (immunology)</term><term>Virus Cultivation (methods)</term><term>Virus Shedding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (analyse)</term><term>Culture virale ()</term><term>Excrétion virale</term><term>Furets</term><term>Mâle</term><term>Protection croisée (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (génétique)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (immunologie)</term><term>Vaccins inactivés (immunologie)</term><term>Vaccins synthétiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protection croisée</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Protection</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Virus Cultivation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Ferrets</term><term>Male</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Culture virale</term><term>Excrétion virale</term><term>Furets</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cross-clade protection against this rapidly evolving virus. We report a comparative evaluation in ferrets of the immunogenicity and cross-protective efficacy of isogenic mammalian cell-grown, live attenuated influenza vaccine (LAIV) and adjuvanted, whole-virus, inactivated influenza vaccine (IIV), produced from a clade 1 H5N1 6:2 reassortant vaccine candidate (caVN1203-Len17rg) based on the cold-adapted A/Leningrad/134/17/57 (H2N2) master donor virus. Two doses of LAIV or IIV provided complete protection against lethal homologous H5N1 virus challenge and a reduction in virus shedding and disease severity after heterologous clade 2.2.1 H5N1 virus challenge and increased virus-specific serum and nasal wash antibody levels. Although both vaccines demonstrated cross-protective efficacy, LAIV induced higher levels of nasal wash IgA and reduction of heterologous virus shedding, compared with IIV. Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><noCountry><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A" last="Belser">Jessica A. Belser</name><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><name sortKey="Cox, Nancy J" sort="Cox, Nancy J" uniqKey="Cox N" first="Nancy J" last="Cox">Nancy J. Cox</name><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O" last="Donis">Ruben O. Donis</name><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G M" last="Heldens">Jacco G M. Heldens</name><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M" last="Katz">Jacqueline M. Katz</name><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I" last="Klimov">Alexander I. Klimov</name><name sortKey="Lu, Xuihua" sort="Lu, Xuihua" uniqKey="Lu X" first="Xuihua" last="Lu">Xuihua Lu</name><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R" last="Maines">Taronna R. Maines</name><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name><name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name><name sortKey="Voeten, J Theo M" sort="Voeten, J Theo M" uniqKey="Voeten J" first="J Theo M" last="Voeten">J Theo M. Voeten</name></noCountry><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Gustin, Kortney M" sort="Gustin, Kortney M" uniqKey="Gustin K" first="Kortney M" last="Gustin">Kortney M. Gustin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000068 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000068 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= 1957
|étape= Analysis
|type= RBID
|clé= pubmed:21957153
|texte= Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i -Sk "pubmed:21957153" \
| HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |